I am interested in following three research fields:
1) As a first project, we have been focusing on the molecular differentiation of DC subsets from bone marrow progenitor cells and their immunogenicity and immune regulation.
2) Second project is the study on the role and functions of p53 and PKR under stress conditions, such as HIV-1 infection, genotoxic stresses, inflammatory stresses etc.
3) Third project is a development of mucosal CTL vaccines using poliovirus vector system.
Education
(BS) 1981.2. Dept. of Microbiology, Seoul National University, Korea
(MS) 1983. 2. Dept. of Microbiology, Seoul National University, Korea
(PhD) 1991 University of Calgary Faculty of Medicine, Canada
Experience
1984 May ~ 1986 Aug Researcher, Korea Tuberculosis Research Institute, Seoul, Korea
1990 Dec ~ 1991 Aug Post-Dr, Julia McFalane Diabetes Research Center, Canada
1991 Sep ~ 1993 Sep Post-Dr, Department of Pathology, Harvard Medical School, USA
1993 Sep ~ 2003 Feb Professor, Hannam University, Daejeon, Korea
2004 Mar ~ present Professor, Sungkyunkwan University, Korea
1998 ~2015 JW Creagene Inc CEO/CTO
2017. 6 ~ Present, KRF SRC (Center for Immune Research on Non-lymphoid Organ, CIRNO) Director
(2023)
Sphingosylphosphorylcholine inhibits plasma cell differentiation and ameliorates experimental autoimmune encephalomyelitis.
FRONTIERS IN IMMUNOLOGY.
14,
(2023)
Discovery of highly immunogenic spleen-resident FCGR3(+)CD103(+) cDC1s differentiated by IL-33-primed ST2(+) basophils.
CELLULAR & MOLECULAR IMMUNOLOGY.
20,
7
(2023)
A nanoadjuvant that dynamically coordinates innate immune stimuli activation enhances cancer immunotherapy and reduces immune cell exhaustion..
NATURE NANOTECHNOLOGY.
18,
4
(2022)
Unique characteristics of lung-resident neutrophils are maintained by PGE2/PKA/Tgm2-mediated signaling.
Blood.
140,
8
(2022)
Siglec-F–expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis.
JOURNAL OF CLINICAL INVESTIGATION.
132,
12
(2021)
Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-0-catenin-driven M2 macrophage.
MOLECULAR THERAPY-ONCOLYTICS.
23,
(2021)
A unique population of neutrophils generated by air pollutant–induced lung damage exacerbates airway inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.
(2021)
Dysregulation of T-FH-B-T-RM lymphocyte cooperation is associated with unfavorable anti-PD-1 responses in EGFR-mutant lung cancer.
NATURE COMMUNICATIONS.
12,
1
(2021)
Epitranscriptomic Approach: To Improve the Efficacy of ICB Therapy by Co-Targeting Intracellular Checkpoint CISH.
CELLS.
10,
9
(2021)
Interactions between NCR(+)ILC3s and the Microbiome in the Airways Shape Asthma Severity.
IMMUNE NETWORK.
21,
4
(2021)
Immunotherapeutic Potential of m6A-Modifiers and MicroRNAs in Controlling Acute Myeloid Leukaemia.
BIOMEDICINES.
9,
6
(2021)
Therapeutic Potential of microRNA Against Th2-associated Immune Disorders.
CURRENT TOPICS IN MEDICINAL CHEMISTRY.
21,
8
(2021)
MicroRNA-based therapeutic approach in Th2-mediated immune disorders.
CURRENT TOPICS IN MEDICINAL CHEMISTRY.
21,
1
(2021)
COVID-19 Vaccines (Revisited) and Oral-Mucosal Vector System as a Potential Vaccine Platform.
VACCINES.
9,
2
(2020)
A membrane-tethering pepducin derived from formyl peptide receptor 3 shows strong therapeutic effects against sepsis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
524,
1
(2019)
CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via beta-Catenin-Mediated Nuclear Translocation.
CANCERS.
11,
10
(2019)
Dendritic Cell-Mediated Th2 Immunity and Immune Disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
20,
9
(2019)
Transendothelial migration (TEM) of in vitro generated dendritic cell vaccine in cancer immunotherapy.
ARCHIVES OF PHARMACAL RESEARCH.
42,
7
(2018)
Junctional adhesion molecules mediate transendothelial migration of dendritic cell vaccine in cancer immunotherapy.
CANCER LETTERS.
434,
Publications
(2009)
바디 (The Body).
성균관대학교 출판부.
Lead author
(2004)
바이러스학.
정문각.
Co-author
Patent/Intellectual Property
oxp3를 발현하고 혈액에만 존재하며 혈액 내 면역항상성을 담당하는 새로운 수지상세포 및 그 응용.
10-2016-0174735.
20170502.
KOREA, REPUBLIC OF
Dab2 유전자가 넉 다운된 수지상 세포를 포함하는 암 예방 또는 치료용 약
학적 조성물.
10-2014-0041687.
20160530.
KOREA, REPUBLIC OF
IFN-α fused protein having interferon-α and cytoplasmic transduction peptide.
EP 9842353.6.
20140910.
EU
IFN-α fused protein having interferon-α and cytoplasmic transduction peptide.
US 13/260,490.
20140107.
UNITED STATES
MLN51유전자 또는 단백질의 신규한 용도 (Novel use of MLN51 gene and protein).
2006-0041646.
20131104.
UNITED STATES
인터페론 알파 및 세포질 잔류성 세포막 투과 펩타이드를 포함하는 IFN-α 융합단백질.
10-2009-0026463.
20131023.
UNITED STATES
인터페론 알파 및 세포질 잔류성 세포막 투과 펩타이드를 포함하는 IFN-α 융합단백질.
10-2009-0026463.
20120912.
KOREA, REPUBLIC OF
인터페론 알파 및 세포질 잔류성 세포막 투과 펩타이드를 포함하는 IFN-α 융합단백질.
10-2009-0026463.
20120912.
KOREA, REPUBLIC OF
전립선암 면역치료용 수지상세포 제조를 위한 PAP 항원의 제조방법.
2009-0008264.
20120702.
KOREA, REPUBLIC OF
종양성장 억제능을 갖는 광역동성 치료 매개 자가유래 수지상 세포.
10-2007-0068524.
20100415.
KOREA, REPUBLIC OF
인간 간암 동물모델 및 이를 이용한 수지상세포 유래 간암면역치료제의 예방 및 치료효능을 분석하는 방법..
10-2007-0048213.
20090527.
KOREA, REPUBLIC OF
준성숙 수지상 세포를 포함하는 류마티스 관절염 치료용 약제학적 조성물..
10-2007-0039629.
20090302.
KOREA, REPUBLIC OF
Cytoplasmic Transduction Peptides and Uses thereof.
4188909.
20080916.
JAPAN
MLN51유전자 또는 단백질의 신규한 용도.
10-0822181.
20080408.
KOREA, REPUBLIC OF
인간 및 비근교계 동물에서 세포독성 Ｔ 임파구 활성을 효과적으로 측정하는 방법정상원, 전춘주, 배용수. 인간 및 비근교계 동물에서 세포독성 T 임파구 활성을 효과적으로 측정하는 방법. 출원인 크레아젠, 등록번호 (2007.06.26).
10-0734525.
20070626.
KOREA, REPUBLIC OF
Advanced oral poliovirus vaccine (ADV-OPV) derived of the possibility of vaccine associated paralytic poliomyelities (VAPP).
US7,138,274.
20061121.
UNITED STATES
인간 전립선암 동물모델 및 이를 이용한 수지상세포-유래 전립선암 면역치료제의 예방 및 치료 효능을 분석하는 방법.
0647847.
20061113.
KOREA, REPUBLIC OF
신규한 CTL-유도용 재조합 폴리오바이러스 벡터 및 백신 조성물.
10-0663093.
20060928.
KOREA, REPUBLIC OF
Cytoplasm transduction peptide and uses thereof.
US7,101,844.
20060905.
UNITED STATES
세포 잔류성 세포ㅓ막 투과 펩타이드 및 이의 용도.
0608558.
20060727.
KOREA, REPUBLIC OF
Honors / Awards
1999. 5. Dongchun Scientist Prize Winner, The Biochemical Society of Korea
2000. 12. New Intelligent Scientist Awardee, The Korean Ministry of Health and Welfare
2002. 11. Hantan Prize Winner, The Hantan Life Science Foundation
2013. 12. The Honorable Awardee for Health and Medical Technology Promotion, The Korean Ministry of Health and Welfare
Conference Paper
(2020)
Kidney Comprises Two Distinct Subsets of CD64+CD11chi Macrophage-like Populations; F4/80+CD11bint Kidney-Resident Macrophages and F4/80lntCD11bhi Macrophage-like Dendritic cells.
2020 대한면역학회 국제학술대회.
KOREA, REPUBLIC OF
(2020)
Exogenous IL-33 promotes anti-tumor immunity via induction of highly immunogenic novel CD103+ dendritic cells.
2020 대한면역학회 국제학술대회.
KOREA, REPUBLIC OF
(2020)
Nrp1+ DC plays crucial role in controlling EAE via induction and maintenance of Nrp1+Helios+ DP-Tregs..
2020 대한면역학회 국제학술대회.
KOREA, REPUBLIC OF
(2020)
TopBP1 plays a crucial role in cDC1 development and DC-mediated antitumor immunity..
2020 대한면역학회 국제학술대회.
KOREA, REPUBLIC OF
(2020)
Hepatic CD103+ DCs Play a Key Role in Liver Homeostasis by Controlling Gut Microbiota-Mediated Liver Damages..
2020대한면역학회 국제학술대회.
KOREA, REPUBLIC OF
(2019)
CISH is epigenetically controlled by microRNA-150 to regulate DC-mediated T-cell immunity..
대한면역학회 국제학술대회.
KOREA, REPUBLIC OF
(2019)
Commensal Gut Microbiota are essential for the immune homeostasis of the Liver via Hepatic Dendritic cells..
대한면역학회 국제학술대회.
KOREA, REPUBLIC OF
(2019)
IL-33 promotes efficacy of DC-mediated tumor suppression via increasing CD103+ DCs and DC immunogenicity associated with cross-priming..
대한면역학회 국제학술대회.
KOREA, REPUBLIC OF
(2019)
TopBP1 plays a crucial role in the conventional dendritic cell (cDC) differentiation from cDC precursor cells..
대한면역학회 국제학술대회.
KOREA, REPUBLIC OF
(2019)
Newly generated Nrp1+ DCs are responsible for the antigen-specific memory T-cell responses during viral infection..
대한면역학회.
KOREA, REPUBLIC OF
(2019)
Dendritic cell-based therapeutic cancer vaccines: past, present and future.
수지상세포학회 추계학술대회.
KOREA, REPUBLIC OF
(2018)
Classified Into IL-33-dependent and IL-33-independent Subsets..
대한면역학회 추계학술대회 초록집.
KOREA, REPUBLIC OF
(2018)
Dendritic Cell-mediated Therapeutic Vaccine against Hepatitis B Virus Using CTP Technology.
대한면역학회 추계학술대회.
KOREA, REPUBLIC OF
(2018)
Epigenetic Control of Dendritic Cell Development From Hematopoietic Stem Cells.
대한면역학회 추계학술대회.
KOREA, REPUBLIC OF
(2018)
Nrp1+ DCs induce antigen-specific memory T-cells during viral infection.
대한면역학회 추계학술대회.
KOREA, REPUBLIC OF
(2018)
Potential Role of M-like DCs in Maintaining Organ Immune Homeostasis in Kidney.
대한면역학회 추계학술대회.
KOREA, REPUBLIC OF
(2018)
Transendothelial Migration of Bone-marrow Derived Dendritic cells in association with JAML..
2017 대한면역학회 추계 국제학술대회.
KOREA, REPUBLIC OF
(2018)
Peritoneal CD103+ Dendritic Cells Control Peritoneal Inflammation Through Regulation Of innate
Immune Cell Migration.
대한면역학회 추계학술대회.
KOREA, REPUBLIC OF
(2018)
Epigenetic control of dendritic cell development from hematopoietic stem cells..
European J Immunology.
GERMANY
(2018)
Potential role of dendritic cells in the development of intestinal dysbiosis-induced Type 2 immunity..
European J of Immunology.
GERMANY
